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The Structure of the DNA Molecule

Access Excellence Classic Collection

Printed Articles/Books:

  1. Watson, J.D., and Crick, F.H.C. 1953. "Molecular Structure of Nucleic Acids. A Structure for Deoxyribose Nucleic Acid." Nature 171:737-738. This short paper is the original presentation of Watson and Crick's hypothesis regarding the double helical structure of the DNA molecule.

  2. Watson, J.D. 1980. The Double Helix: A personal account of the discovery of the structure of DNA. W.W. Norton and Co., New York. Read Watson's own words as he describes the people and the investigations, interactions, and deductions that led to the discovery of the double helical structure of the DNA molecule.

  3. Felsenfeld, G. 1985. "DNA." Scientific American 253(4):58-67. Abstract: The genetic material's double helix, the fundamental molecule of life, is variable and also flexible. It interacts with regulatory proteins and other molecules to transfer its hereditary message. Subjects: deoxyribonucleic acid (DNA), DNA replication, DNA transcription, double helix, gene expression, nucleotide sequence, recombinant DNA, supercoiling.

  4. Mirsky, A.E.. 1968. "The Discovery Of DNA." Scientific American 218(6):78-88. Abstract: In 1869 Friedrich Miescher found a substance in white blood cells that he called "nuclein." Cell biologists saw that it was a constituent of chromosomes and hence must play a major role in heredity. Subjects: chromatin, deoxyribonucleic acid (DNA), hereditary material, leukocyte, Miescher, nucleus, spermatozoon nucleus.

  5. Micklos, D.A., and Freyer, G.A. 1990. DNA Science. A First Course in Recombinant DNA Technology. Pages 26-29. Cold Spring Harbor Laboratory Press and Carolina Biological Supply Company. An excellent examination of the series of investigations leading up to the elucidation of the structure of the DNA molecule.

  6. Crick, F. H. C. "Nucleic Acids" / September, 1957 / page 188 US, page Intl. Abstract: These polymers appear to carry the pattern of living matter from one generation to the next. Their basic chain consists of sugars joined by phosphates. Attached to the sugars, in turn, are bases. Subjects: chromosome, deoxyribonucleic acid (DNA), genetic code, polymers, protein synthesis, ribonucleic acid (RNA).

  7. Crick, F. H. C. "The Structure Of The Hereditary Material" / October, 1954 / page 54 US, page Intl. Abstract: An account of the investigations which have led to the formulation of an understandable structure for DNA. The chemical reactions of this material within the nucleus govern the process of reproduction. Subjects: deoxyribonucleic acid (DNA), double helix, genetic code, X-ray crystallography.

  8. Crick, F. H. C. 1988. What Mad Pursuit. A personal view of scientific discovery. Basic Books, Inc., Publishers. New York.

  9. King, R.B., Stansfield, W.D. 1990. "Chronology." From A Dictionary of Genetics, 4th ed. Oxford Unversity Press, NY.

The World Wide Web:

  1. Image Library of Biological Macromolecules
    This page contains a gopher menu which allows you to select graphics showing the DNA nucleotides (singly, in pairs, or in a DNA strand), torsional angle in nucleotides, and strand direction in nucleic acids.

  2. Primer on Molecular Genetics-Introduction
    A short discussion of DNA structure by the Department of Energy. The text includes hot links to 4 separate graphics including "The Human Genome at Four Levels of Detail" and "DNA Structure."

Kits and Demonstrations:

Note: Following are three examples of the many DNA-oriented kits which are available from scientific supply companies. Please obtain complete descriptions and price lists from the vendor prior to purchase. Access Excellence does not endorse any individual product.

  1. DNA SIMULATION KIT, Carolina Biological Supply Company, 2700 York Road, Burlington, NC 27215, 1993. Cat.#:17-1030
    kit subj: DNA

  2. NUCLEIC ACID STRUCTURE - DNA/RNA VIEWMASTER KIT, Frey Scientific, 905 Hickory Lane, Mansfield, OH 44901-8101, 1993.
    kit subj: DNA

  3. DNA MOLECULAR MODEL KIT, Ward's Biology, PO Box 92912, Rochester, New York, 14692-9012. Kit subj: DNA.

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