Here I just have a rather complicated slide of a bacterium that's divided and some of the target sites for potential antibacterial action which I just went over. The ribosome factory being hit by the macrolides and so forth. The protein that's coming off that ribosome is represented as the small circular figures, the messenger RNA that's being read by the ribosomes is that single strand with a 5' end and the protein that it made; the quinolone hitting the DNA. This target hasn't been really looked at very well, hitting that septum (cross wall separating a dividing cell). There's just ongoing studies there. Protein secretion will get to some mechanisms of resistance which includes efflux. I'll mention that later. Cell wall biosynthesis the classical target for cephalosporin and penicillins. Synthesis and degradation of the components for energy is yet another possibility. For instance, you can interfere with metabolism; the sulfur dugs interfere with the folic acid pathway. As long as the pathway hasn't been mutated, the compound will be effective. But there is a drug that they use for a combination drug even if the organism has figured out how to bypass a blockade in a metabolic pathway. I'll mention that. That's one of the ways we're trying to attack this resistant problem.

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