Pharmaceutical Industry's Approach to   Help Resolve the Problem Identify the primary targets as those representing the toughest antibiotic-resistant pathogens currently seen in the clinic. Focus on developing agents which are effective against the most highly and broadly resistant organisms, i.e. those presenting the greatest medical need. (pen/mac-R St.pneumoniae, MRSA, and Enterococcus faecalis/faecium) Conduct basic research to recognize emerging mechanisms of resistance before they become a clinical problem.