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Aging and Cancer: Are Telomeres and Telomerase the Connection?

Host: Gail Tucker
Presenter: Jerry W. Shay, Ph.D.


    1.) Kim, N-W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., and Shay J. W. Specific association of human telomerase activity with immortal cells and cancer. Science, 266:2011-2015, 1994.

    2.) Bodnar, A. G., Ouellete, M., Frolkis, M., Holt, S. E., Chiu, C-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., and Wright, W. E. Extension of lifespan by introduction of telomerase in normal human cells. Science 279:349-352, 1998.

    3.) Shay, J. W. Telomerase in cancer: Diagnostic, prognostic and therapeutic implications. Cancer J. Scientific Amer., 4:26-34, 1998.

    Internet address for supplementary links to information about telomeres and telomerase go to the following URL: http://www.swmed.edu/home_pages/cellbio/shay/links.html

    On Dr. Shay's home page there are photographs and additional resources including a list of frequently asked questions. http://www.swmed.edu/home_pages/cellbio/shay/index.html

Post your question for Dr. Shay.


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